Hykos

1. McCain 2. Romney 3. Giuliani

srsly /goes to starbucks

tell that to a narcoleptic.

http://www.wired.com/science/discoveries/n...eep_deprivation In what sounds like a dream for millions of tired coffee drinkers, Darpa-funded scientists might have found a drug that will eliminate sleepiness. A nasal spray containing a naturally occurring brain hormone called orexin A reversed the effects of sleep deprivation in monkeys, allowing them to perform like well-rested monkeys on cognitive tests. The discovery's first application will probably be in treatment of the severe sleep disorder narcolepsy. The treatment is "a totally new route for increasing arousal, and the new study shows it to be relatively benign," said Jerome Siegel, a professor of psychiatry at UCLA and a co-author of the paper. "It reduces sleepiness without causing edginess." Orexin A is a promising candidate to become a "sleep replacement" drug. For decades, stimulants have been used to combat sleepiness, but they can be addictive and often have side effects, including raising blood pressure or causing mood swings. The military, for example, administers amphetamines to pilots flying long distances, and has funded research into new drugs like the stimulant modafinil (.pdf) and orexin A in an effort to help troops stay awake with the fewest side effects. The monkeys were deprived of sleep for 30 to 36 hours and then given either orexin A or a saline placebo before taking standard cognitive tests. The monkeys given orexin A in a nasal spray scored about the same as alert monkeys, while the saline-control group was severely impaired. The study, published in the Dec. 26 edition of The Journal of Neuroscience, found orexin A not only restored monkeys' cognitive abilities but made their brains look "awake" in PET scans. Siegel said that orexin A is unique in that it only had an impact on sleepy monkeys, not alert ones, and that it is "specific in reversing the effects of sleepiness" without other impacts on the brain. Such a product could be widely desired by the more than 70 percent of Americans who the National Sleep Foundation estimates get less than the generally recommended eight hours of sleep per night (.pdf). The research follows the discovery by Siegel that the absence of orexin A appears to cause narcolepsy. That finding pointed to a major role for the peptide's absence in causing sleepiness. It stood to reason that if the deficit of orexin A makes people sleepy, adding it back into the brain would reduce the effects, said Siegel. "What we've been doing so far is increasing arousal without dealing with the underlying problem," he said. "If the underlying deficit is a loss of orexin, and it clearly is, then the best treatment would be orexin." Dr. Michael Twery, director of the National Center on Sleep Disorders Research, said that while research into drugs for sleepiness is "very interesting," he cautioned that the long-term consequences of not sleeping were not well-known. Both Twery and Siegel noted that it is unclear whether or not treating the brain chemistry behind sleepiness would alleviate the other problems associated with sleep deprivation. "New research indicates that not getting enough sleep is associated with increased risk of cardiovascular disease and metabolic disorders," said Twery. Still, Siegel said that Americans already recognize that sleepiness is a problem and have long treated it with a variety of stimulants. "We have to realize that we are already living in a society where we are already self-medicating with caffeine," he said. He also said that modafinil, which is marketed as Provigil by Cephalon and Alertec in Canada, has become widely used by healthy individuals for managing sleepiness. "We have these other precedents, and it's not clear that you can't use orexin A temporarily to reduce sleep," said Siegel. "On the other hand, you'd have to be a fool to advocate taking this and reducing sleep as much as possible." Sleep advocates probably won't have to worry about orexin A reaching drugstore shelves for many years. Any commercial treatment using the substance would need approval from the Food and Drug Administration, which can take more than a decade.

lumbermine, check. bucket will not be needed. by me. at least. I can't speak for others.

ill be there. need directions to the new place though

umm... they don't make Trans Ams anymore. Still, they probably should have used that camero from transformers. At least it would still be a GM.

It's a setting in Firefox. Find it, change it, problem over. =)

Infomercial crap turns man blue: http://consumerist.com/336219/odd-gadget-turns-man-blue http://www.boingboing.net/Picture%204-59.jpg Video of blue man: http://abclocal.go.com/kfsn/story?section=...&id=5843725 Interesting flickr pool of science tattoos: http://www.flickr.com/photos/carlzimmer/se...57601351535771/ damnit I only got to 16.

http://cache.gizmodo.com/assets/resources/2007/12/butt_sharpener.jpg

Random Fun ridiculousness: live action Dragonball movie in production. (why???) Staring Spike from Buffy, Ando from Heroes, Chow Yun-fat (that's just sad) and a bunch of random white and asian people. Why do things like this get made??

A lot of people give rubber mats for xmas?

Awesome, Steve. I got nothing to add, but I hope others do. It's slow as molasses in January around here and I need something to keep me occupied.

http://www.shacknews.com/onearticle.x/50464 I can't believe this game is still being worked on.

I) Gandalf! What are these dwarves doing in my kitchen? II) Oh no, trolls! ---Where's Gandalf? ---Oh, there he is. He saved us. II) Oh no, goblins! ---Where's Gandalf? ---Oh, there he is. He saved us. ---And brought eagles! III) What a spooky little frog man! ---Good thing I found this magic invisibility ring. IV) Oh no, spiders! ---Good thing I found this magic invisibility ring. V) Oh no, irate elves! ---Good thing I found this magic invisibility ring. VI) Oh no, a dragon! ---Where's the door to his cave? Oh, there it is. ---Good thing I found this magic invisibility ring. VII) Oh no, armies of elves and goblins and humans! ---Where's Gandalf? ---Oh, there he is. He saved us through cooperation. ---And brought eagles!

Check her oil Steve. [insert dip stick joke here]

lawl. I love how they phrase that as if it would totally be up to Raimi to decide that. Like he would just call up New Line and be like "ok guys, I'm doing this. give it to me". heh That's about the most speculative thing ever. There's probably more than a few notable directors who would want to do that film, but from what i've read Jackson never said he definetly wasn't directing.

yesm

http://img104.imageshack.us/img104/1776/poofr5.jpg makes a festive upper decker

The Hobbit and a sequel based on unpublished written material from Tolkien to be made next year. The Hobbit will come out in 2010 and the sequel will come out in 2011. /geek Press Release from New Line / Peter Jackson / MGM: ACADEMY AWARD-WINNER PETER JACKSON AND NEW LINE CINEMA JOIN WITH MGM TO PRODUCE “THE HOBBIT,” EAGERLY-ANTICIPATED FANTASY ADVENTURE EPIC NEW LINE AND MGM TO CO-PRODUCE AND SHARE WORLDWIDE DISTRIBUTION RIGHTS PETER JACKSON AND FRAN WALSH TO EXECUTIVE PRODUCE TWO FILMS BASED ON “THE HOBBIT” Los Angeles, CA (Tuesday, December 18, 2007) Academy Award-winning filmmaker Peter Jackson; Harry Sloan, Chairman and CEO, Metro-Goldwyn-Mayer Studios Inc. (MGM); Bob Shaye and Michael Lynne, Co-Chairmen and Co-CEOs of New Line Cinema have jointly announced today that they have entered into the following series of agreements: * MGM and New Line will co-finance and co-distribute two films, “The Hobbit” and a sequel to “The Hobbit.” New Line will distribute in North America and MGM will distribute internationally. * Peter Jackson and Fran Walsh will serve as Executive Producers of two films based on “The Hobbit.” New Line will manage the production of the films, which will be shot simultaneously. * Peter Jackson and New Line have settled all litigation relating to the “Lord of the Rings” (LOTR) Trilogy. Said Peter Jackson, “I’m very pleased that we’ve been able to put our differences behind us, so that we may begin a new chapter with our old friends at New Line. ‘The Lord of the Rings’ is a legacy we proudly share with Bob and Michael, and together, we share that legacy with millions of loyal fans all over the world. We are delighted to continue our journey through Middle Earth. I also want to thank Harry Sloan and our new friends at MGM for helping us find the common ground necessary to continue that journey.” “Peter Jackson has proven himself as the filmmaker who can bring the extraordinary imagination of Tolkien to life and we full heartedly agree with the fans worldwide who know he should be making ‘The Hobbit,’” said Sloan, MGM’s Chairman and CEO. “Now that we are all in agreement on ‘The Hobbit,’ we can focus on assembling the production team that will capture this phenomenal tale on film.” Bob Shaye, New Line Co-Chairman and Co-CEO comments, “We are very pleased we have been able to resolve our differences, and that Peter and Fran will be actively and creatively involved with ‘The Hobbit’ movies. We know they will bring the same passion, care and talent to these films that they so ably accomplished with ‘The Lord of the Rings’ Trilogy.” “Peter is a visionary filmmaker, and he broke new ground with ‘The Lord of the Rings,’” notes Michael Lynne, New Line Co-Chairman and Co-CEO. “We’re delighted he’s back for ‘The Hobbit’ films and that the Tolkien saga will continue with his imprint. We greatly appreciate the efforts of Harry Sloan, who has been instrumental in helping us reach our new accord.” The two “Hobbit” films – “The Hobbit” and its sequel – are scheduled to be shot simultaneously, with pre-production beginning as soon as possible. Principal photography is tentatively set for a 2009 start, with the intention of “The Hobbit” release slated for 2010 and its sequel the following year, in 2011. The Oscar-winning, critically-acclaimed LOTR Trilogy grossed nearly $3 billion worldwide at the box-office. In 2003, “Return of the King” swept the Academy Awards, winning all of the eleven categories in which it was nominated, including Best Picture – the first ever Best Picture win for a fantasy film. The Trilogy’s production was also unprecedented at the time. For more information about “The Hobbit” films, please visit www.TheHobbitBlog.com.

I think he fibbed on some of his answers

Judging by the bank heist scene, people think it's makeup used as some sort of war paint. His origins in Dark Knight are suppose to be true to the original appearence in the comics in the 50's, which means a bath in a chemical vat permanently turned his skin/hair/lips different colors. IMO the new Joker looks more like how a chemical change would look. Brutal and effed up. Jack Nicholson just looked like a clown in make up.

28. Damn kids.

I think it will be better. And to prove it I have a math equation: Batman - http://img137.imageshack.us/img137/3818/holmesnv6.jpg+ http://img137.imageshack.us/img137/520/maggiewf5.jpg= Win